Robert W. Obstet Gynecol May. Ovarian stimulation followed by IUI for infertile women younger than 40 should probably be confined to cycles with no more than 2 mature follicles. Ovarian stimulation followed by intrauterine insemination IUI increases the chances of multiple gestation.
To examine this risk, investigators conducted a retrospective study of 24, patients undergoing 50, IUI cycles at a single fertility center. Ovarian stimulation was conducted with agents including clomiphene citrate, letrozole, and gonadotropins. In women younger than 38, raising the number of mature follicles at IUI from 1 to 5 was associated with an increase in clinical pregnancy rates from The twin and multiple rates also vary from fertility clinic to clinic.
Twin rates differ based on how carefully they track ovulation stimulation during fertility drug use and how many embryos they routinely transfer during IVF. While having twins may sound like the kind of two-for-one deal any couple would love to have after experiencing infertility, it really is best to aim for one healthy baby. Your doctor can reduce the odds of multiples with careful monitoring and single-embryo transfer during IVF.
However, if you do conceive twins or more, know that good prenatal care can reduce your risk of complications. There are also many positive benefits to having twins. A family history of identical twins will not necessarily increase your chances of having them yourself, although the offspring of male identical twins are more likely to have them.
However, you are more likely to have twins if there are fraternal twins in your family. If there are fraternal twins on both your mother's and father's sides of the family, your chances of having fraternal twins yourself are even higher. Many of the factors that increase your odds of having twins are out of your control, like your family history and height, for example. But there are other ways to improve your odds if you're hoping for multiples.
Factors that increase the chance of twins include: consuming high amounts of dairy foods, being over the age of 30, and conceiving while breastfeeding. Many fertility drugs including Clomid, Gonal-F, and Follistim also increase the odds of a twin pregnancy. Get diet and wellness tips to help your kids stay healthy and happy. Adashi EY, Gutman R. Delayed childbearing as a growing, previously unrecognized contributor to the national plural birth excess.
Obstet Gynecol. Multiple pregnancy and birth: Twins, triplets and high-order multiples. Trakia J Sci. Gleicher N. Principles of Medical Therapy in Pregnancy. Steinman G. Mechanisms of twinning: VIII.
Maternal height, insulin-like growth factor and twinning rate. J Reprod Med. Mechanisms of twinning. Sex preference and lactation. Shur N. The genetics of twinning: from splitting eggs to breaking paradigms.
University of Rochester Medical Center. Health Encyclopedia. Overview of Multiple Pregnancy. Centers for Disease Control and Prevention. Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer. Fertil Steril. Case report: Successful of a spontaneous quadruplet pregnancy. Published by Elsevier Ltd. All rights reserved. Or, should we try to get 3, or more than 3?
Does the age of the woman matter much? Does the type of stimulating drug matter? Does the peak estrogen hormone level before ovulation matter? How this study was done: The stated objective of the study: To determine the relationship of follicle numbers and estradiol E2 levels to multiple implantations in human menopausal gonadotropin HMG injectable gonadotropins and clomiphene citrate Clomid, Serophene cycles. Design of the study : Fifteen-year prospective study.
Clomiphene citrate cycles - Clomid Of clomiphene pregnancies, 14 8. No triplet implantations occurred after age 33 in clomiphene cycles. In HMG cycles, the number of follicles decreased with age, from 7. The implantation rates per follicle were identical for all three stimulation regimens and decreased sharply after age No triplet implantations occurred in the clomiphene cycles in which E2 was measured.
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